Join the Metro Times Press Club: Because no news is bad news.

Monday, May 4, 2020

Beaumont begins studying two common drugs' potential to treat COVID-19

Posted By on Mon, May 4, 2020 at 12:03 PM

BEAUMONT HEALTH
  • Beaumont Health

Researchers at Beaumont Hospital in Royal Oak have received approval to launch a clinical trial to determine whether two common drugs — naltrexone and ketamine — are an effective treatment for COVID-19.

The randomized trial will involve adult patients hospitalized at Beaumont in Royal Oak. Researchers are hoping the two drugs, taken together, will lessen the severity of COVID-19 symptoms in patients in the early and late stages of the virus.



“There is an urgent need to develop new treatments for COVID-19 using easily available and affordable medications,” Dr. Matthew Sims, director of infectious disease research at Beaumont and the study’s principal investigator, says in a news release. “Ideal new treatments for COVID-19 would help halt the progression of the disease in patients with mild cases prior to the need for ventilators, and provide a rescue treatment for patients with severe cases of the virus.”

Low doses of naltrexone have been used to treat pain and inflammation in multiple sclerosis, Crohn’s disease, fibromyalgia, and other pain conditions. Ketamine is an anesthetic drug that has shown anti-inflammatory effects.

The United States Food and Drug Administration’s Investigational New Drug program gave Beaumont the green light to start the clinical trial, which has already begun enrolling patients.

“We need a two-pronged strategy to combat COVID-19,” Dr. Annas Aljassem, the study’s co-investigator, says. “Low doses of naltrexone, a drug approved for treating alcoholism and opiate addiction, as well as ketamine, a drug approved as an anesthetic, may be able to interrupt the inflammation that causes the worst COVID-19 symptoms.”

"The drugs have the potential to save lives,” Sims says.

“The addition of these two medications, as immunomodulators, to the treatment regimen of patients with COVID-19 has potential to decrease the severity of this disease by reducing the autoimmune, hyperinflammatory stages of the virus which is destructive to normal tissue and, when unchecked, rapidly leads to death,” Sims says.

Stay on top of Detroit news and views. Sign up for our weekly issue newsletter delivered each Wednesday.

Tags: , , , , , , , , , ,

We welcome readers to submit letters regarding articles and content in Detroit Metro Times. Letters should be a minimum of 150 words, refer to content that has appeared on Detroit Metro Times, and must include the writer's full name, address, and phone number for verification purposes. No attachments will be considered. Writers of letters selected for publication will be notified via email. Letters may be edited and shortened for space.

Email us at letters@metrotimes.com.

Detroit Metro Times works for you, and your support is essential.

Our small but mighty local team works tirelessly to bring you high-quality, uncensored news and cultural coverage of Detroit and beyond.

Unlike many newspapers, ours is free – and we'd like to keep it that way, because we believe, now more than ever, everyone deserves access to accurate, independent coverage of their community.

Whether it's a one-time acknowledgement of this article or an ongoing pledge, your support helps keep Detroit's true free press free.

Read the Digital Print Issue

September 23, 2020

View more issues

Newsletters

Never miss a beat

Sign Up Now

Subscribe now to get the latest news delivered right to your inbox.

Best Things to Do In Detroit